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Chunk #26 — Results — Conditional analyses and probabilistic finemapping further refine AN association signals

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Multiomic prioritisation of risk genes for anorexia nervosa.
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6351/1RP13-238F13.5Brain spinal cord cervical c-1GTEx5.010.97NANA10: 125 919 795–10: 127 999 4241/1NXPE1TestisGTEx6.021NANA11: 114 833 710–11: 116 383 0641/1C3orf62Brain dorsolateral prefrontal cortexCommonMind Consortium−7.190.423−7.13 (9.71 × 10−13)- cortexNA3: 47 777 774–3: 49 313 9784/384TREX1Brain cortexGTEx−6.950.449−3.2575 (1.1 × 10−3) – Nucleus accumbens basal ganglia−2.1349 (0.032) -DLPFC3: 49 317 338–3: 51 815 6875/476PROS1Brain cortexGTEx5.210.8950.07 (0.94) -whole bloodNA3: 94 256 654–3: 95 306 1752/3PRKAR2AArtery tibialGTEx−6.950.814NANA3: 49 317 338–3: 51 815 6875/476Finemapped genes with moderate or strong evidence of a causal effect on AN (PIP > 0.4). Tissue indicates which tissue the expression weights were derived from, Ref name indicates the group/consortium responsible for eQTL generation, Zfinemap indicates the estimated Z score association, PIP indicates the posterior inclusion probability and region indicates the GRCh37 genomic region the credible set was derived from. Credible set size indicates the number of genes in the credible set when prioritising brain or any tissue. All genes are in the credible set. ZTWAS (P) -tissue and ZPWAS (P) -tissue indicates the TWAS and PWAS Z score and p value associated with the most significant tissue for each association. No spliceWAS associations are available for these eight genes.