Pathway analysis was performed on the conditionally independent (N = 97) and finemapped credible set of genes (N=8) using g:Profiler (Ensembl 103, Ensembl Genomes 50). We focused on pathways that were enriched for either of these input sets of genes that survived FDR correction (FDR < 0.05) and had at least three intersecting genes with the input list. Firstly, the conditionally independent genes were overrepresented amongst pathways related to the presynaptic active zone (overlapping genes = STX19, CTNND1, CTBP2, CTNNB1) (online Supplementary Table S6). While the genes prioritised by finemapping were overrepresented in the regulation of immune system process (overlapping genes = MST1, TREX1, PRKAR2A, PROS1) (online Supplementary Table S7). We note that as there were only eight genes that survived our finemapping pipeline that pathway analyses using this set of genes is somewhat underpowered.
