Further evidence for a genetic component to level of response to alcohol was provided by a genome-wide segregation analysis that evaluated subjective response to alcohol challenge in sibpairs. In that study, nine chromosome regions were identified with LOD scores between 2.2 and 3.2 suggesting potential regions of interest in the genome that may contribute to the variance in alcohol responsivity (Wilhelmsen et al., 2003). An expanded dataset, collected in the same laboratory, also identified 5 areas of the genome with LOD scores between 2.2 and 2.6 for level of response to alcohol in sibpairs (Schuckit et al., 2005).
