To understand the regional specificity of global ancestry-associated differentially expressed features, we compared DEGs from each brain region and observed extensive sharing across regions. Specifically, we observed 1,210 DEGs (47.1%) shared between at least two brain regions, where all pairwise overlaps demonstrated significant enrichment (Fisher’s exact test, P < 0.01; Fig. 2c). Moreover, 478 DEGs (18.6%) were shared among at least three brain regions, with 112 (4.4%) of these DEGs (Monte Carlo simulation, P < 1 × 10−5) shared across all four brain regions.
