As noted, three independent datasets were employed in these OD-phenotype analyses, in three phases. EAs and AAs were analyzed separately in each phase. In Phase 1, GWAS was conducted in a discovery dataset containing 5,697 subjects. In Phase 2, the first replication phase, SNPs with p-values <10−4 in either or both populations combined were tested for association in the SAGE dataset including 4,063 subjects. In Phase 3, the second replication phase, SNPs with p-values <10−4 in either population in the Phase 2 analyses were evaluated in a set of 2,549 unrelated subjects ascertained in the same manner as the Phase 1 sample. Meta-analyses were conducted in a combined sample of 12,309 subjects. Analyses of symptom count accounted for comorbidity with other SD symptoms (sympcountadj).
