The subjects who participated in the GWAS and the replication study were enrolled by the BioBank Japan Project [7] at the Institute of Medical Science, the University of Tokyo. All participants provided written informed consent as approved by the ethical committees of the RIKEN Yokohama Institute and the Institute of Medical Science, the University of Tokyo. This study has been approved by the ethical committees of the RIKEN Yokohama Institute and the Institute of Medical Science, the University of Tokyo.