Chunk #33 — HOW DO NEURAL SIGNATURES ASSOCIATED WITH AUD HELP ELUCIDATE THE ROLE OF BRAIN FUNCTION IN THE RISK AND CONSEQUENCES OF ALCOHOL USE AND AUD ACROSS THE LIFESPAN? — How do genomic factors influence brain functioning across the lifespan and contribute to antecedents and resilience for AUD? — Genome‐wide association studies (GWAS) of neurophysiological phenotypes
drinks on one occasion and DSM‐5 AUD symptoms in COGA families and associated with alcohol drinker status and alcohol intake frequency in the UK Biobank, an independent sample. 126 These findings provide support for the role of genetic variants on chromosome 18q23 in regulating both neural connectivity and alcohol use behaviors, potentially via dysregulated myelination. Interestingly, these variants were also associated with corpus callosum volume in a subset of COGA participants and UK Biobank participants. COGA will continue leading efforts to replicate and expand this work independently and in collaboration with the ENIGMA Consortium‐EEG Workgroup 117 (11 studies, total N: 17,168).
