Chunk #34 — HOW DO NEURAL SIGNATURES ASSOCIATED WITH AUD HELP ELUCIDATE THE ROLE OF BRAIN FUNCTION IN THE RISK AND CONSEQUENCES OF ALCOHOL USE AND AUD ACROSS THE LIFESPAN? — How do genomic factors influence brain functioning across the lifespan and contribute to antecedents and resilience for AUD? — Polygenic scores (PGS) and neurophysiological phenotypes
The advent of polygenic scores (PGS), note, also described as polygenic risk scores (PRS), 127 , 128 which are an aggregate of genetic information from GWAS, permits characterization of the complex interplay of genetic influences on neurodevelopmental trajectories of brain function and risk for AUD. COGA has examined whether polygenic score for DSM‐IV AD (AD PGS) 129 was associated with developmental trajectories of interhemispheric and intrahemispheric neural connectivity from adolescence to young adulthood (aged 12–32). AD PGS was found to affect development of frontal‐central alpha connectivity in young adult males, but not females, 130 and was also associated with decreased planning and problem solving skills and poorer visuospatial working memory (Figure S2). 131 In another recent study, COGA researchers examined the associations between P3 amplitude, PGS for behavioral dyscontrol (EXT PGS), and self‐report of externalizing behaviors. 122 , 132 Investigators examined these associations among adolescents (12–17) and young adults (18–32) of both European and African ancestry. Both the EXT PGS and P3 amplitude were associated with externalizing behaviors, but the EXT PGS was not significantly associated with P3 amplitude. The
