Chunk #35 — HOW DO NEURAL SIGNATURES ASSOCIATED WITH AUD HELP ELUCIDATE THE ROLE OF BRAIN FUNCTION IN THE RISK AND CONSEQUENCES OF ALCOHOL USE AND AUD ACROSS THE LIFESPAN? — How do genomic factors influence brain functioning across the lifespan and contribute to antecedents and resilience for AUD? — Polygenic scores (PGS) and neurophysiological phenotypes
examined these associations among adolescents (12–17) and young adults (18–32) of both European and African ancestry. Both the EXT PGS and P3 amplitude were associated with externalizing behaviors, but the EXT PGS was not significantly associated with P3 amplitude. The results suggest that genetic liability for behavioral dyscontrol and P3 amplitude are each uniquely contributing to the expression of externalizing behavior, perhaps indexing different facets of externalizing risk. 132
