Chunk #36 — HOW DO NEURAL SIGNATURES ASSOCIATED WITH AUD HELP ELUCIDATE THE ROLE OF BRAIN FUNCTION IN THE RISK AND CONSEQUENCES OF ALCOHOL USE AND AUD ACROSS THE LIFESPAN? — How do genomic factors influence brain functioning across the lifespan and contribute to antecedents and resilience for AUD? — Polygenic scores (PGS) and neurophysiological phenotypes
Across linkage studies, GWAS, and PGS, COGA is uniquely positioned to address multiple facets of complex clinical phenomena, with expertise in translation of findings between brain function, genomics and substance use. The consortia continues to work collaboratively internally and externally to enhance our understanding of mechanisms underlying AUD and related disorders, including in understudied ancestrally diverse populations.
