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Chunk #21 — 8. Cannabinoids in Depression and Anxiety — 8.2. Evidence for the Involvement of the ECS in Depression, Anxiety, and Stress

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Endocannabinoid System and Exogenous Cannabinoids in Depression and Anxiety: A Review.
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Thus, most preclinical studies underline an important role for the ECS in anxiety- and depression-like behaviors, and that the ECS seems to be compromised in the animal models of depression, anxiety, and stress exposure.