In humans, there are multiple lines of evidence suggesting a role for the ECS in depression, anxiety, and stress. Most of the available evidence for perturbations affecting ECS in depression and anxiety derive from two major sources: post-mortem tissues and clinical measurements of eCB levels, notably AEA and 2AG, in the blood or cerebrospinal fluid (CSF) of patients. The other observations are related to cannabis use for recreational or self-medication purposes, which will be treated independently.
