The gene information, annotation and the interactions data is updated automatically except for pathways (see the ‘Database details’ section from the homepage of ToppGene Suite for a list of data resources, coverage and version details and dates of last updates). The ‘Database details’ is a dynamic web page that reads the in-memory data structures and displays the counts and statistics of the live data. As the data are refreshed, the counts and statistics are automatically updated. Users can enter the training and test sets of genes of interest as queries from the interface, and the application will display enriched themes in the training set genes along with annotated prioritized test genes. Alternately, users can enter training sets and use the extended gene list from the PPIN as a test set to rank the genes in the interactome using either functional annotations or network features.
