ToppGene Suite for gene list enrichment analysis and candidate gene prioritization.
paper
Cited
Public
- Authors
- Chen, Jing; Bardes, Eric E; Aronow, Bruce J; Jegga, Anil G
- Year
- 2009
- Journal
- Nucleic acids research
- PMID
- 19465376
- DOI
- 10.1093/nar/gkp427
- PMCID
- PMC2703978
ToppGene Suite (http://toppgene.cchmc.org; this web site is free and open to all users and does not require a login to access) is a one-stop portal for (i) gene list functional enrichment, (ii) candidate gene prioritization using either functional annotations or network analysis and (iii) identification and prioritization of novel disease candidate genes in the interactome. Functional annotation-based disease candidate gene prioritization uses a fuzzy-based similarity measure to compute the similarity between any two genes based on semantic annotations. The similarity scores from individual features are combined into an overall score using statistical meta-analysis. A P-value of each annotation of a test gene is derived by random sampling of the whole genome. The protein-protein interaction network (PPIN)-based disease candidate gene prioritization uses social and Web networks analysis algorithms (extended versions of the PageRank and HITS algorithms, and the K-Step Markov method). We demonstrate the utility of ToppGene Suite using 20 recently reported GWAS-based gene-disease associations (including novel disease genes) representing five diseases. ToppGene ranked 19 of 20 (95%) candidate genes within the top 20%, while ToppNet ranked 12 of 16 (75%) candidate genes among the top 20%.
Schematic representation of workflow and methodology in ToppGene Suite applications. (A) Genes in the training set are selected based on their attributes or current gene annotations (genes associated with a disease, phenotype, pathway or a GO term). (B) The test gene source can be candidate genes from linkage analysis studies or genes differentially expressed in a particular disease or phenotype or genes from the interactome. (C) ToppFunEnriched terms of the gene annotations and sequence features, namely, GO: Molecular Function, GO: Biological Process, Mouse Phenotype, Pathways, Protein Interactions, Protein Domains, transcription factor-binding sites, miRNA-target genes, disease-gene associations, drug-gene interactions, and Gene Expression, compiled from various data sources and also used to build the training set gene profile. (C and D) ToppGeneβa similarity score is generated for each annotation of each test gene by comparing to the enriched terms in the training set of genes. The final prioritized gene list is then computed based on the aggregated values of the 14 similarity scores. (E and F) ToppNetβTraining and test set genes are mapped to a proteinβprotein interaction network. Scoring and ranking of test set genes are based on the relative location to all of the training set genes using global network-distance measures in the PPIN.
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Next β
| Name | Type |
|---|---|
| AK3L1 local | gene |
| ALDH1A1 | gene |
| bipolar disorder | phenotype |
| Bonferroni correction | drug |
| cardiomyopathy | phenotype |
| CCR3 | gene |
| celiac disease | phenotype |
| Colt local | drug |
| Crohn's disease | phenotype |
| disease candidate genes local | gene |
| disease genes | gene |
| gene g | gene |
| GOLEM local | drug |
| HITS with Priors local | drug |
| human phenotype local | phenotype |
| hypergeometric distribution local | drug |
| IL12A local | gene |
| IL12B local | gene |
| IL18R1 | gene |
| IRGM | gene |
| Jakarta Commons-Math local | drug |
| KLF12 local | gene |
| K-step Markov local | drug |
| MC4R | gene |
| mouse phenotype local | phenotype |
| MST1 | gene |
| MYBPC3 | gene |
| NKX2-3 local | gene |
| NLRP3 | gene |
| obesity | phenotype |
| PageRank with Priors local | drug |
| proteinβprotein interaction network (PPIN) local | drug |
| PTPN23 local | gene |
| RGS19 | gene |
| RORA | gene |
| RORB | gene |
| SH2B3 local | gene |
| STAT3 | gene |
| TAGAP local | gene |
| ToppFun local | drug |
| ToppNet local | drug |
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| Apoptosis Genes as a Key to Identification of Inverse Comorbidity of Huntington's Disease and Cancer. | Bragina EY et al. | β | 2023 | β |
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| A p-Tyr42 RhoA Inhibitor Promotes the Regeneration of Human Corneal Endothelial Cells by Ameliorating Cellular Senescence. | Kim HJ et al. | β | 2023 | β |
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| Associative gene networks reveal novel candidates important for ADHD and dyslexia comorbidity. | Hongyao HE et al. | β | 2023 | β |
| A topographic atlas defines developmental origins of cell heterogeneity in the human embryonic lung. | Sountoulidis A et al. | β | 2023 | β |
| ATP1A3 as a target for isolating neuron-specific extracellular vesicles from human brain and biofluids. | You Y et al. | β | 2023 | β |
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| Autism-linked NLGN3 is a key regulator of gonadotropin-releasing hormone deficiency. | Oleari R et al. | β | 2023 | β |
| BAFF and APRIL counterregulate susceptibility to inflammation-induced preterm birth. | Doll JR et al. | β | 2023 | β |
| Baseline Peripheral Blood Mononuclear Cell Transcriptomics Before Ustekinumab Treatment Is Linked With Crohn's Disease Clinical Response at 1 Year. | Granot M et al. | β | 2023 | β |
| Beneficial Effect of Vitamin D on Non-Alcoholic Fatty Liver Disease (NAFLD) Progression in the Zebrafish Model. | Grinberg L et al. | β | 2023 | β |
| BIGKnock: fine-mapping gene-based associations via knockoff analysis of biobank-scale data. | Ma S et al. | β | 2023 | β |
| Bioinformatic analysis of gene expression data reveals Src family protein tyrosine kinases as key players in androgenetic alopecia. | Premanand A et al. | β | 2023 | β |
| Bioinformatics and Next-Generation Data Analysis for Identification of Genes and Molecular Pathways Involved in Subjects with Diabetes and Obesity. | Ganekal P et al. | β | 2023 | β |
| Bisphenol B and bisphenol AF exposure enhances uterine diseases risks in mouse. | Wu X et al. | β | 2023 | β |
| Brain proteomic analysis implicates actin filament processes and injury response in resilience to Alzheimer's disease. | Huang Z et al. | β | 2023 | β |
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| Cerebral blood flow changes and their genetic mechanisms in major depressive disorder: a combined neuroimaging and transcriptome study. | Sun X et al. | β | 2023 | β |
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| COMMD10 Is Essential for Neural Plate Development during Embryogenesis. | Phan KP et al. | β | 2023 | β |
| Complement factor B is essential for the proper function of the peripheral auditory system. | Brown LN et al. | β | 2023 | β |
| Computational drug repurposing by exploiting large-scale gene expression data: Strategy, methods and applications. | He H et al. | β | 2023 | β |
| Conceiving complexity: Biological mechanisms underpinning the lasting effect of pregnancy on multiple sclerosis outcomes. | Campagna MP et al. | β | 2023 | β |
| Conserved gene signatures shared among <i>MAPT</i> mutations reveal defects in calcium signaling. | Minaya MA et al. | β | 2023 | β |
| DeepGenePrior: A deep learning model for prioritizing genes affected by copy number variants. | Rahaie Z et al. | β | 2023 | β |
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| Development of a proteomic signature associated with severe disease for patients with COVID-19 using data from 5 multicenter, randomized, controlled, and prospective studies. | Castro-Pearson S et al. | β | 2023 | β |
| Divergent contributions of coding and noncoding sequences to initial high-altitude adaptation in passerine birds endemic to the Qinghai-Tibet Plateau. | Hao Y et al. | β | 2023 | β |
| Dynamic chromatin organization and regulatory interactions in human endothelial cell differentiation. | Alavattam KG et al. | β | 2023 | β |
| Early ART reduces viral seeding and innate immunity in liver and lungs of SIV-infected macaques. | Clain JA et al. | β | 2023 | β |
| Early Deregulation of Cholangiocyte NR0B2 During Primary Sclerosing Cholangitis. | Desterke C et al. | β | 2023 | β |
| Effects of urban living environments on mental health in adults. | Xu J et al. | β | 2023 | β |
| EGFR and Lyn inhibition augments regorafenib induced cell death in sorafenib resistant 3D tumor spheroid model. | SarΔ±yar E et al. | β | 2023 | β |
| EMC3 regulates mesenchymal cell survival via control of the mitotic spindle assembly. | Tang X et al. | β | 2023 | β |
| Empowering biologists to decode omics data: the Genekitr R package and web server. | Liu Y et al. | β | 2023 | β |
| Endothelial cells differentiated from patient dermal fibroblast-derived induced pluripotent stem cells resemble vascular malformations of port-wine birthmark. | Nguyen V et al. | β | 2023 | β |
| Engineered bone marrow as a clinically relevant ex vivo model for primary bone cancer research and drug screening. | Griffin KH et al. | β | 2023 | β |
| Enteroendocrine Cells Protect the Stem Cell Niche by Regulating Crypt Metabolism in Response to Nutrients. | McCauley HA et al. | β | 2023 | β |
| Eosinophils promote effector functions of lung group 2 innate lymphoid cells in allergic airway inflammation in mice. | LeSuer WE et al. | β | 2023 | β |
| Erythrocyte miRNA-92a-3p interactions with PfEMP1 as determinants of clinical malaria. | Prabhu SR et al. | β | 2023 | β |
| Establishment of killer whale (Orcinus orca) primary fibroblast cell cultures and their transcriptomic responses to pollutant exposure. | BjΓΈrneset J et al. | β | 2023 | β |
| Evaluation of Feeding Beta-Hydroxy-Beta-Methylbutyrate (HMB) to Mouse Dams during Gestation on Birth Weight and Growth Variation of Offspring. | Clarke AS et al. | β | 2023 | β |
| Exploring ceRNA networks for key biomarkers in breast cancer subtypes and immune regulation. | Shariatmadar Taleghani A et al. | β | 2023 | β |
| Exploring genome-wide differentiation and signatures of selection in Italian and North American Holstein populations. | Persichilli C et al. | β | 2023 | β |
| Exploring the Functional Basis of Epigenetic Aging in Relation to Body Fat Phenotypes in the Norfolk Island Cohort. | Cao TV et al. | β | 2023 | β |
| Extension of mRNA poly(A) tails and 3'UTRs during neuronal differentiation exhibits variable association with post-transcriptional dynamics. | Kiltschewskij DJ et al. | β | 2023 | β |
| FAM3L: Feature-Aware Multi-Modal Metric Learning for Integrative Survival Analysis of Human Cancers. | Shao W et al. | β | 2023 | β |
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| FOXP1 orchestrates neurogenesis in human cortical basal radial glial cells. | Park SHE et al. | β | 2023 | β |
| Functional genomics analysis identifies loss of HNF1B function as a cause of Mayer-Rokitansky-KΓΌster-Hauser syndrome. | Thomson E et al. | β | 2023 | β |
| Functional hierarchy of the angular gyrus and its underlying genetic architecture. | Song Y et al. | β | 2023 | β |
| GATA6-AS1 Regulates Intestinal Epithelial Mitochondrial Functions, and its Reduced Expression is Linked to Intestinal Inflammation and Less Favourable Disease Course in Ulcerative Colitis. | Sosnovski KE et al. | β | 2023 | β |
| Gene biomarkers and classifiers for various subtypes of HTLV-1-caused ATLL cancer identified by a combination of differential gene coβexpression and support vector machine algorithms. | Zarei Ghobadi M et al. | β | 2023 | β |
| Gene expression studies of WT1 mutant Wilms tumor cell lines in the frame work of published kidney development data reveals their early kidney stem cell origin. | Royer-Pokora B et al. | β | 2023 | β |
| Genetic mechanisms underlying brain functional homotopy: a combined transcriptome and resting-state functional MRI study. | Zhao H et al. | β | 2023 | β |
| Genetic mechanisms underlying gray matter volume changes in patients with drug-naive first-episode schizophrenia. | Xu X et al. | β | 2023 | β |
| Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy. | Kiryluk K et al. | β | 2023 | β |
| Genome-Wide Association Study and Transcriptome of Japanese Patients with Developmental Dysplasia of the Hip Demonstrates an Association with the Ferroptosis Signaling Pathway. | Mori Y et al. | β | 2023 | β |
| Germ-cell-specific transcriptome analysis illuminates the chromatin and ubiquitin pathway in autism spectrum disorders. | Furukawa S et al. | β | 2023 | β |
| Gibbs process distinguishes survival and reveals contact-inhibition genes in Glioblastoma multiforme. | Jahedi A et al. | β | 2023 | β |
| GluN2D Subunit in Parvalbumin Interneurons Regulates Prefrontal Cortex Feedforward Inhibitory Circuit and Molecular Networks Relevant to Schizophrenia. | Gawande DY et al. | β | 2023 | β |
| GPS2-mediated regulation of the adipocyte secretome modulates adipose tissue remodeling at the onset of diet-induced obesity. | English J et al. | β | 2023 | β |
| Growth and differentiation of human induced pluripotent stem cell (hiPSC)-derived kidney organoids using fully synthetic peptide hydrogels. | Treacy NJ et al. | β | 2023 | β |
| HFrEF subphenotypes based on 4210 repeatedly measured circulating proteins are driven by different biological mechanisms. | Petersen TB et al. | β | 2023 | β |
| Identification and Interaction Analysis of Molecular Markers in Pancreatic Ductal Adenocarcinoma by Bioinformatics and Next-Generation Sequencing Data Analysis. | Giriyappagoudar M et al. | β | 2023 | β |
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| Identification of Novel Candidate Genes for Familial Thyroid Cancer by Whole Exome Sequencing. | Tous C et al. | β | 2023 | β |
| Identification of Novel Core Genes Involved in Malignant Transformation of Inflamed Colon Tissue Using a Computational Biology Approach and Verification in Murine Models. | Markov AV et al. | β | 2023 | β |
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| Identifying the Common Cell-Free DNA Biomarkers across Seven Major Cancer Types. | Luo M et al. | β | 2023 | β |
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| Insilco prediction of the role of the FriZZled5 gene in colorectal cancer. | Hosseini-Abgir A et al. | β | 2023 | β |
| Integrated analysis using ToppMiR uncovers altered miRNA-βmRNA regulatory networks in pediatric hepatocellular carcinoma-A pilot study. | Whyte SS et al. | β | 2023 | β |
| Integrated genomic and single-cell transcriptomic analyses reveal clonal evolution and immune signature in donor cell leukemia after haploidentical allogeneic hematopoietic stem cell transplantation. | Chen H et al. | β | 2023 | β |
| Integrated multiomics analysis of chromosome 19 miRNA cluster in bladder cancer. | Ware AP et al. | β | 2023 | β |
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| Integrative omics-analysis of lipid metabolism regulation by peroxisome proliferator-activated receptor a and b agonists in male Atlantic cod. | Eide M et al. | β | 2023 | β |
| Intrinsic cancer cell phosphoinositide 3-kinase Ξ΄ regulates fibrosis and vascular development in cholangiocarcinoma. | Bou Malham V et al. | β | 2023 | β |
| Investigating the effects of chronic low-dose radiation exposure in the liver of a hypothermic zebrafish model. | Cahill T et al. | β | 2023 | β |
| Kidney Organoids Generated Using an Allelic Series of NPHS2 Point Variants Reveal Distinct Intracellular Podocin Mistrafficking. | Dorison A et al. | β | 2023 | β |
| Knowledge-Driven Mechanistic Enrichment of the Preeclampsia Ignorome. | Callahan TJ et al. | β | 2023 | β |
| Lipid metabolic reprogramming of hepatic CD4<sup>+</sup> T cells during SIV infection. | Clain JA et al. | β | 2023 | β |
| Longitudinal DNA methylation profiling of the rectal mucosa identifies cell-specific signatures of disease status, severity and clinical outcomes in ulcerative colitis cell-specific DNA methylation signatures of UC. | Venkateswaran S et al. | β | 2023 | β |
| MicroRNA-Based Discovery of Biomarkers, Therapeutic Targets, and Repositioning Drugs for Breast Cancer. | Ye Q et al. | β | 2023 | β |
| MicroRNA Signatures in Cartilage Ageing and Osteoarthritis. | Balaskas P et al. | β | 2023 | β |
| Mild dehydration effects on the murine kidney single-nucleus transcriptome and chromatin accessibility. | Huynh NV et al. | β | 2023 | β |
| Mitochondrial dysfunction-associated microbiota establishes a transmissible refractory response to anti-TNF therapy during ulcerative colitis. | PeΓ±a-Cearra A et al. | β | 2023 | β |
| Modeling Blast Crisis Using Mutagenized Chronic Myeloid Leukemia-Derived Induced Pluripotent Stem Cells (iPSCs). | Imeri J et al. | β | 2023 | β |
| Modeling RET-Rearranged Non-Small Cell Lung Cancer (NSCLC): Generation of Lung Progenitor Cells (LPCs) from Patient-Derived Induced Pluripotent Stem Cells (iPSCs). | Marcoux P et al. | β | 2023 | β |
| Modulation of miR-29 influences myocardial compliance likely through coordinated regulation of calcium handling and extracellular matrix. | Zhang X et al. | β | 2023 | β |
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| MTSS1 curtails lung adenocarcinoma immune evasion by promoting AIP4-mediated PD-L1 monoubiquitination and lysosomal degradation. | Wang Y et al. | β | 2023 | β |
| Multi-omics analysis revealing the interplay between gut microbiome and the host following opioid use. | Kolli U et al. | β | 2023 | β |
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| Novel causative variants of VEXAS in UBA1 detected through whole genome transcriptome sequencing in a large cohort of hematological malignancies. | Sakuma M et al. | β | 2023 | β |
| NREP contributes to development of NAFLD by regulating one-carbon metabolism in primary human hepatocytes. | De Jesus DF et al. | β | 2023 | β |
| OCT4 induces long-lived dedifferentiated kidney progenitors poised to redifferentiate in 3D kidney spheroids. | Omer D et al. | β | 2023 | β |
| One bout of endurance exercise does not change gene expression or proliferation in a C26 colon carcinoma in immunocompetent mice. | Mahnic N et al. | β | 2023 | β |
| Oxidative stress induces lysosomal membrane permeabilization and ceramide accumulation in retinal pigment epithelial cells. | Zhang KR et al. | β | 2023 | β |
| Parity is associated with long-term differences in DNA methylation at genes related to neural plasticity in multiple sclerosis. | Campagna MP et al. | β | 2023 | β |
| Pathogenetic Insights into Developmental Coordination Disorder Reveal Substantial Overlap with Movement Disorders. | Garofalo M et al. | β | 2023 | β |
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| Pervasive Sharing of Causal Genetic Risk Factors Contributes to Clinical and Molecular Overlap between SjΓΆgren's Disease and Systemic Lupus Erythematosus. | Chau K et al. | β | 2023 | β |
| Post-irradiation intratumoral heterogeneity modulates response to immune checkpoint inhibition therapy in a murine melanoma model. | Wang J et al. | β | 2023 | β |
| Primary Colorectal Tumor Displays Differential Genomic Expression Profiles Associated with Hepatic and Peritoneal Metastases. | Gelli M et al. | β | 2023 | β |
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| Profiling the peripheral immune response to ex vivo TNF stimulation in untreated juvenile idiopathic arthritis using single cell RNA sequencing. | Imbach KJ et al. | β | 2023 | β |
| RAAS-deficient organoids indicate delayed angiogenesis as a possible cause for autosomal recessive renal tubular dysgenesis. | Pode-Shakked N et al. | β | 2023 | β |
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| Resting-state brain functional alterations and their genetic mechanisms in drug-naive first-episode psychosis. | Li Q et al. | β | 2023 | β |
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| Rewiring of miRNA-mRNA bipartite co-expression network as a novel way to understand the prostate cancer related players. | Naghizadeh MM et al. | β | 2023 | β |
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| Schizophrenia-associated NRXN1 deletions induce developmental-timing- and cell-type-specific vulnerabilities in human brain organoids. | Sebastian R et al. | β | 2023 | β |
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| Single-cell analysis reveals prognostic fibroblast subpopulations linked to molecular and immunological subtypes of lung cancer. | Hanley CJ et al. | β | 2023 | β |
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| Single-cell transcriptomics identifies a WNT7A-FZD5 signaling axis that maintains fallopian tube stem cells in patient-derived organoids. | Alsaadi A et al. | β | 2023 | β |
| Single-cell transcriptomics uncovers a non-autonomous Tbx1-dependent genetic program controlling cardiac neural crest cell development. | De Bono C et al. | β | 2023 | β |
| siRNA-Mediated <i>Timp1</i> Silencing Inhibited the Inflammatory Phenotype during Acute Lung Injury. | Chernikov IV et al. | β | 2023 | β |
| Small RNA signatures of the anterior cruciate ligament from patients with knee joint osteoarthritis. | Kharaz YA et al. | β | 2023 | β |
| Spatial Gene Expression Changes in the Mouse Heart After Base-Targeted Irradiation. | Walls GM et al. | β | 2023 | β |
| Spatial transcriptomics reveals unique gene expression changes in different brain regions after sleep deprivation. | Vanrobaeys Y et al. | β | 2023 | β |
| Specific processing of meiosis-related transcript is linked to final maturation in human oocytes. | Pietroforte S et al. | β | 2023 | β |
| Sperm Motility Annotated Genes: Are They Associated with Impaired Fecundity? | Abu-Halima M et al. | β | 2023 | β |
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| Synthetic oleanane triterpenoids suppress <i>MYB</i> oncogene activity and sensitize T-cell acute lymphoblastic leukemia cells to chemotherapy. | Tejera Nevado P et al. | β | 2023 | β |
| Systematic investigation of the homology sequences around the human fusion gene breakpoints in pan-cancer - bioinformatics study for a potential link to MMEJ. | Kim P et al. | β | 2023 | β |
| Targeting lysine-specific demethylase 1 (KDM1A/LSD1) impairs colorectal cancer tumorigenesis by affecting cancer cells stemness, motility, and differentiation. | Antona A et al. | β | 2023 | β |
| Targeting P21-activated kinase suppresses proliferation and enhances chemosensitivity in T-cell lymphoblastic lymphoma. | Su N et al. | β | 2023 | β |
| Targeting the ADPKD methylome using nanoparticle-mediated combination therapy. | Trinh A et al. | β | 2023 | β |
| Testing sulforaphane as a strategy against toxic chemicals of public health concern by toxicogenomic data analysis: Friend or foe at the gene level - Colorectal carcinoma case study. | BaraliΔ K et al. | β | 2023 | β |
| The Angiogenesis Inhibitor Isthmin-1 (ISM1) Is Overexpressed in Experimental Models of Glomerulopathy and Impairs the Viability of Podocytes. | Sahiri V et al. | β | 2023 | β |
| The Effects of a Mixture of Cadmium, Lead, and Mercury on Metabolic Syndrome and Its Components, as well as Cognitive Impairment: Genes, MicroRNAs, Transcription Factors, and Sponge Relationships : The Effects of a Mixture of Cadmium, Lead, and Mercury on Metabolic Syndrome and Its Components, as well as Cognitive Impairment: Genes, MicroRNAs, Transcription Factors, and Sponge Relationships. | Nguyen HD et al. | β | 2023 | β |
| The hsa-miR-516a-5p and hsa-miR-516b-5p microRNAs reduce the migration and invasion on T98G glioblastoma cell line. | Fonseca ΓYG et al. | β | 2023 | β |
| The minichromosome maintenance complex drives esophageal basal zone hyperplasia. | Rochman M et al. | β | 2023 | β |
| The molecular genetic landscape of human brain size variation. | Seidlitz J et al. | β | 2023 | β |
| The proteomic landscape shows oncologic relevance in cystitis glandularis. | Kim JY et al. | β | 2023 | β |
| The Regulation Network of Glycerolipid Metabolism as Coregulators of Immunotherapy-Related Myocarditis. | Yang X et al. | β | 2023 | β |
| The Rho GTPase exchange factor Vav2 promotes extensive age-dependent rewiring of the hair follicle stem cell transcriptome. | Lorenzo-MartΓn LF et al. | β | 2023 | β |
| The Stria Vascularis in Mice and Humans Is an Early Site of Age-Related Cochlear Degeneration, Macrophage Dysfunction, and Inflammation. | Lang H et al. | β | 2023 | β |
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| Transcriptome Profiling Reveals Enhanced Mitochondrial Activity as a Cold Adaptive Strategy to Hypothermia in Zebrafish Muscle. | Cahill T et al. | β | 2023 | β |
| Transcriptomic data of bevacizumab-adapted colorectal adenocarcinoma cells HCT-116. | Cesare S et al. | β | 2023 | β |
| Transcriptomic Differences Underlying the Activin-A Induced Large Osteoclast Formation in Both Healthy Control and Fibrodysplasia Ossificans Progressiva Osteoclasts. | Schoenmaker T et al. | β | 2023 | β |
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| Wide identification of chemical constituents in fermented licorice and explore its efficacy of anti-neurodegeneration by combining quasi-targeted metabolomics and in-depth bioinformatics. | Wang X et al. | β | 2023 | β |
| 3'UTR-Seq analysis of chicken abdominal adipose tissue reveals widespread intron retention in 3'UTR and provides insight into molecular basis of feed efficiency. | Wang Z et al. | β | 2022 | β |
| A Bayesian framework to integrate multi-level genome-scale data for Autism risk gene prioritization. | Ji Y et al. | β | 2022 | β |
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| A cognitive neurogenetic approach to uncovering the structure of executive functions. | Feng J et al. | β | 2022 | β |
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| ADAP1 promotes latent HIV-1 reactivation by selectively tuning KRAS-ERK-AP-1 T cell signaling-transcriptional axis. | Ramirez NP et al. | β | 2022 | β |
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| Genomics, convergent neuroscience and progress in understanding autism spectrum disorder. | Willsey HR et al. | β | 2022 | β |
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| Increased Expression of the RBPMS Splice Variants Inhibits Cell Proliferation in Ovarian Cancer Cells. | Rabelo-FernΓ‘ndez RJ et al. | β | 2022 | β |
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| Integrated Bioinformatics Analysis to Identify Alternative Therapeutic Targets for Alzheimer's Disease: Insights from a Synaptic Machinery Perspective. | Ceylan H | β | 2022 | β |
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| miR-383 Regulates Hepatic Lipid Homeostasis and Response to Dengue Virus Infection. | Ahmed N et al. | β | 2022 | β |
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| Multi-Omics Immune Interaction Networks in Lung Cancer Tumorigenesis, Proliferation, and Survival. | Ye Q et al. | β | 2022 | β |
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| State of the Science for Kidney Disorders in Phelan-McDermid Syndrome: UPK3A, FBLN1, WNT7B, and CELSR1 as Candidate Genes. | McCoy MD et al. | β | 2022 | β |
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| The antitumoral activity of TLR7 ligands is corrupted by the microenvironment of pancreatic tumors. | Rouanet M et al. | β | 2022 | β |
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| 29th Annual GP2A Medicinal Chemistry Conference. | Helesbeux JJ et al. | β | 2021 | β |
| Aberrant <i>GATA2</i> Activation in Pediatric B-Cell Acute Lymphoblastic Leukemia. | Wang H et al. | β | 2021 | β |
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| Metabolic Variation Dictates Cardiac Pathogenesis in Patients With Tetralogy of Fallot. | Liu J et al. | β | 2021 | β |
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| Pan-Cancer Analysis of Immune Complement Signature C3/C5/C3AR1/C5AR1 in Association with Tumor Immune Evasion and Therapy Resistance. | Lawal B et al. | β | 2021 | β |
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| Potential Molecular Mechanisms and Remdesivir Treatment for Acute Respiratory Syndrome Corona Virus 2 Infection/COVID 19 Through RNA Sequencing and Bioinformatics Analysis. | Prashanth G et al. | β | 2021 | β |
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| Proteomics Profiling with SWATH-MS Quantitative Analysis of Changes in the Human Brain with HIV Infection Reveals a Differential Impact on the Frontal and Temporal Lobes. | Doke M et al. | β | 2021 | β |
| Quantitative phosphoproteomics reveals GSK3A substrate network is involved in the cryodamage of sperm motility. | Wang J et al. | β | 2021 | β |
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| Regulation of Neuroendocrine-like Differentiation in Prostate Cancer by Non-Coding RNAs. | SlabΓ‘kovΓ‘ E et al. | β | 2021 | β |
| Relationships of Telomere Homeostasis with Oxidative Stress and Cardiac Dysfunction in Human Ischaemic Hearts. | TarazΓ³n E et al. | β | 2021 | β |
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| Sequential Defects in Cardiac Lineage Commitment and Maturation Cause Hypoplastic Left Heart Syndrome. | Krane M et al. | β | 2021 | β |
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| TLGP: a flexible transfer learning algorithm for gene prioritization based on heterogeneous source domain. | Wang Y et al. | β | 2021 | β |
| TPSC: a module detection method based on topology potential and spectral clustering in weighted networks and its application in gene co-expression module discovery. | Liu Y et al. | β | 2021 | β |
| Traces of SARS-CoV-2 RNA in Peripheral Blood Cells of Patients with COVID-19. | Moustafa A et al. | β | 2021 | β |
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| Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation. | Heller S et al. | β | 2021 | β |
| Transcriptome-wide <i>In Vitro</i> Effects of Aspirin on Patient-derived Normal Colon Organoids. | Devall MAM et al. | β | 2021 | β |
| Vaccine Hyporesponse Induced by Individual Antibiotic Treatment in Mice and Non-Human Primates Is Diminished upon Recovery of the Gut Microbiome. | Swaminathan G et al. | β | 2021 | β |
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