independent of known disease-related genes, is used for disease candidate gene identification, especially in cases where there is little or no prior knowledge about the disease. The latter application, on the other hand, uses a ‘seed’ list as training to score the neighboring genes. It avoids bias toward highly connected ‘hub’ genes, but the candidate gene is searched in a local network region unlike ToppNet, and the user has to provide the size of the neighborhood region in the network.
