in their prioritization approaches even though the mouse is the key model organism for the analysis of mammalian developmental, physiological and disease processes (15). Additionally, previous reports (16,17) have shown that a direct comparison of human and mouse phenotypes allowed rapid recognition of disease causal genes. In an earlier study (10), we have demonstrated that employing mouse phenotype data in fact improves candidate gene prioritization. Through various examples, we also demonstrated (10) that ToppGene performs better than SUSPECTS (9), PROSPECTR (3) and ENDEAVOUR (5), three commonly used methods in candidate gene prioritization.
