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Chunk #13 — Results — hiPSC-Astrocytes and Primary Human Fetal Astrocytes Share Similar Transcriptional Profiles

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An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells.
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SHOX2; SLIT1Reactome TCR signalingG23194190.14.74 × 10−60.002876HLA-DQA1; HLA-DRB1; HLA-DRB5Nervous system developmentS151736618.84.82 × 10−60.002876CNTN4; LMX1B; LY6H; SHOX2; SLIT1Biocarta TCRA pathwayG22195492.86.23 × 10−60.003549HLA-DRA; HLA-DRB1Reactome co-stimulation by the CD28 familyG23195271.19.77 × 10−60.005322HLA-DQA1; HLA-DRB1; HLA-DRB5Reactome interferon-γ signalingG23195764.81.29 × 10−50.006553HLA-DQA1; HLA-DRB1; HLA-DRB5Biocarta IL-5 pathwayG221973521.31 × 10−50.006553HLA-DRA; HLA-DRB1AxonogenesisG13284259.71.71 × 10−50.007939CNTN4; OTX2; SLIT1Biocarta asbcell pathwayG221983081.74 × 10−50.007939HLA-DRA; HLA-DRB1Neuron differentiationS13177356.61.92 × 10−50.00858CNTN4; LMX1B; SLIT1MSigDB (http://software.broadinstitute.org/gsea/msigdb) is a collection of gene annotations, including gene ontology, and functional pathways. Overlap size: the number of genes shared between a query gene set (e.g., genes in group 1, G1) and a gene set in MSigDB (e.g., antigen processing and presentation). Group size: the number of genes in a query gene set. MSigDB size: the number of genes in MSigDB gene set. FE, fold enrichment; FDR, false discovery rate.