In drinkers, the cerebellum, bilateral dorsal ACC (dACC) extending to superior frontal gyrus (SFG), bilateral thalamus, left postcentral gyrus (PoG), and right superior parietal lobule (SPL) extending to angular gyrus (AG) decreased activation to higher AUDIT score (Table 3; Figure 2a). No brain regions showed activation that positively correlated with AUDIT score. The right middle occipital cortex (MOG) increased activations to longer years of alcohol use, and the left TPJ extending to SMG, right inferior frontal gyrus (IFG) extending to STG, bilateral primary motor cortices (PMC) and PoG, left SPL bordering precuneus, and mid-cingulate cortex (MCC) decreased activations in association with longer duration of alcohol use (Table 3; Figure 2b).
