We evaluated all imaging results at a voxel threshold of p<.005, uncorrected, combined with a cluster size threshold of 29 contiguous voxels estimated with a Monte-Carlo simulation using AlphaSim to correct for multiple comparison across the whole brain (see Methods). One-sample t test of SS>GS for all participants identified regional activations to response inhibition for the whole brain (Figure 1a and 1b). A two-sample t test showed greater activities in the right supramarginal gyrus (SMG), superior temporal gyrus (STG), and left temporoparietal junction (TPJ) extending to the middle temporal gyrus (MTG) in drinkers as compared to non-drinkers. On the other hand, non-drinkers showed greater activation in bilateral rostral anterior cingulate cortex (rACC) than drinkers (Table 2; Figure 1c).
