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Chunk #1 — Introduction

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Atypical effective connectivity from the frontal cortex to striatum in alcohol use disorder.
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Several researchers have proposed that personality traits associated with heightened negative emotionality and decreased constraint may serve as predictive factors for the development of AUD [3–6]. Individuals with high levels of constraint (opposite to impulsivity) exhibit robust self-regulation, refrain from engaging in physically perilous or exhilarating activities, and uphold conventional values and norms for behavior [7]. Although several longitudinal studies have demonstrated that traits associated with heightened impulsivity during adolescence serve as predictors of AUD in adulthood [8–10], a consensus has yet to be reached regarding whether impulsivity arises as a consequence of prolonged alcohol exposure or predates alcohol consumption, thereby augmenting individuals’ vulnerability to addiction. Furthermore, the intricate relationship between impulsivity, alterations in brain function, and AUDs remains unclear.