Alcohol misuse and dependence present significant global public health concerns, with high rates of morbidity and mortality [1]. Alcohol use disorder (AUD) is a chronic relapsing condition characterized by an impulsive compulsion to consume alcohol and an inability to inhibit its consumption despite adverse consequences [2]. Despite recent advances in understanding the neurobiological mechanisms underlying alcohol-induced neuroadaptations, significant challenges persist in elucidating how different brain regions interact. Moreover, while pharmaceutical and behavioral interventions have been employed to reduce alcohol consumption or promote abstinence, their efficacy remains modest and underutilized. Critically, the identification of personality traits that render individuals susceptible to alcohol use and the development of AUD, along with elucidating the neurobiological mechanisms associated with AUD and identifying potential clinical biomarkers through neuroimaging, can significantly enhance diagnostic accuracy for AUD at various stages.
