In the liver, tesa treatment produced the most genomic perturbations (Figure S2A). As expected, known PPAR targets were enriched for each PPAR agonist treatment in the liver (Figure S2A). Overrepresentation analysis (ORA) revealed enrichment of pathways and biological processes related to PPAR signaling, fatty acid metabolism and peroxisome signaling (Figure S2B). This corroborates previous data and also serves to validate our microarray experiments. Hepatic stellate cells were the only enriched cell type (other than hepatocytes) in liver genes that were up-regulated by tesa treatment (Figure S2A). The hypergeometric p-statistics for the cell-type enrichment analyses for all tissues are provided (Table S5).
