Tesa, feno and beza activate different combinations of PPAR isotypes with varying affinity (Table S6), and this is expected to produce unique genomic signatures. To understand the relationship between the feno-, tesa- and beza-regulated genes, we evaluated the degree of overlap between the top-tables (Figure 4) and found that it is greater than expected by chance for all overlapping gene regions (hypergeometric p < 0.05). There are many commonly regulated genes among the three PPAR agonists, but each also regulates a unique set of target genes.
