The present report focuses only on differences in the insula, due to a priori interest in this brain region. Volume of interest (VOI) analyses of BOLD signal data were conducted on bilateral insula. Left and right insula masks were generated based on the Anatomical Automatic Labeling (AAL) atlas using WFU PickAtlas software toolbox 43–45. Effect sizes for reward and loss anticipation activation in the VOIs were extracted from individual contrasts of interest using MarsBaR Region of interest toolbox 46. T-tests were conducted in SPSS to compare the insula effect sizes between A-carriers and GG GABRA2 genotypes and haplotypes. Pearson correlation was conducted in SPSS to test the relationship between Impulsiveness and insula effect sizes.
