Personality and genotype data were available for 436 subjects (rs279826) and 431 subjects (rs279858) respectively (449 total). LD for both SNPs in our sample is r2 = 0.78, resulting in two major haplotypes, A-A and G-G, corresponding to 93% of the total haplotypes. We found both GABRA2 SNPs and the haplotype associated with the Impulsiveness facet of the Neuroticism domain in our overall sample (Table 2). These polymorphisms explain about 1.6% of the total variance of Impulsiveness. Overall, subjects with the GG genotype for both SNPs and haplotypes showed higher scores on the NEO-PI-R Impulsiveness facet (rs279858 F = 6.3; p = 0.02; rs279826 F = 6.9; p = 0.008; haplotype F = 5.2; p = 0.01). These results remain significant when controlled for family history and age (rs279858 p = 0.016; rs279826 p = 0.012; haplotype p = 0.032). Regressing out the effect of each SNP confirms that they are not independent. Genotype*sex interaction was observed as a secondary analysis for rs279826 (F = 2.9; p = 0.05) indicating that the genetic effect was observed in females (rs279858 p
