Regressing out the effect of each SNP confirms that they are not independent. Genotype*sex interaction was observed as a secondary analysis for rs279826 (F = 2.9; p = 0.05) indicating that the genetic effect was observed in females (rs279858 p = 0.012; rs279826 p = 0.006; haplotype p = 0.009) and the association was stronger when controlled for family history and age (rs279858 p = 0.011; rs279826 p = 0.002; haplotype p = 0.006) (Table 2).
