Since GABRA2 variants were previously found to be associated with alcoholism, we also tested these Impulsiveness-associated SNPs for association with percentage of alcohol dependence symptom. In the presence of any alcoholic symptoms the GG genotype for both SNPs rs279858 (N = 443, β = −0.676; p = 0.02) and rs279826 (N = 448, β = −0.562; p = 0.05) and GG/GG haplotype (N = 408, β = −0.703; p = 0.02) were likely to have alcohol dependence symptoms compared to A carriers. In the case of the haplotype, this association became significant when gender was included as covariate where females with the GG/GG haplotype were likely to have a higher percentage of alcoholic symptoms compared to A carriers (β = 0.7653; p = 0.0053).
