Magnetic resonance imaging studies have shown frontal lobe volume losses in alcoholic subjects (Pfefferbaum et al 1997), and prefrontal neurobehavioral dysfunctioning has been frequently observed in alcoholics with and without Korsakoff’s syndrome (Kril et al 1997; Oscar-Berman 2000). Such abnormalities have been identified with reduced regional blood flow measurements (Dally et al 1988; Melgaard et al 1990) and with measurements of lower glucose metabolism throughout the brain (including prefrontal cortex) during alcohol intoxication (Volkow et al 1990).
