Many studies have found the frontal lobes to be more susceptible to alcohol-related brain damage than other cerebral regions. These results were based on neuro-psychological and neuroradiological data (Ratti et al 1999; Oscar-Berman 2000; Sullivan 2000; Mann et al 2001). In addition, studies of brain pathology at autopsy have revealed decreased neuron density in the frontal cortex of alcoholics (eg, see Kril et al 1997). Kril and collaborators (1997) established that 15%–23% of cortical neurons are selectively lost from the frontal association cortex following chronic alcohol consumption.
