but the two systems are distinctly different. Primary OFC connections are with the medial thalamus (the magnocellular region of the dorsomedial nucleus), the hypothalamus, the ventrolateral portion of the head of the caudate, and the amygdala (Fuster 1997). The OFC is host to a variety of neurochemical influences because of its intimate connectivity with hypothalamic and limbic sites, but it appears to be linked more with forebrain cholinergic than with catecholaminergic systems (Oscar-Berman et al 1991). In general, compared with dorsolateral cortex, OFC is more densely interconnected with limbic sites and with the basal forebrain, and less interconnected with other neocortical association areas.
