ADHD-PGS was negatively associated with seven neurocognitive measures (Fig. 3), with the strongest association for the WRAT-4 test (beta = −0.09, P = 1.09 × 10−10). ADHD-PGS was associated with measures of executive control (attention: beta = −0.08, P = 3.94 × 10−8; working memory: beta = −0.05, P = 1.56 × 10−3), complex cognition (verbal reasoning: beta = −0.08, P = 1.31 × 10−10; non-verbal reasoning: beta = −0.05, P = 1.08 × 10−3; spatial reasoning: beta = −0.06, P = 5.15 × 10−5) and one measure of episodic memory (facial memory: beta = −0.05, P = 3.23 × 10−3) (Supplementary Table 20). The negative association of ADHD risk variants with executive functions, especially attention, is in line with the inattention problems often observed in individuals with ADHD.
