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Chunk #8 — Background

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A stable pattern of EEG spectral coherence distinguishes children with autism from neuro-typical controls - a large case control study.
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as well as similarly decreased interhemispheric coherence. Lazarev et al. [24] evaluated, with EEG during photic stimulation at different frequencies, 14 6- to 14-year-old children with ASD in comparison to a neuro-typical control group. The authors reported an ASD-specific coherence increase at the frequencies of stimulation in the left but not the right hemisphere, as compared to the neuro-typical subjects. Resting, that is, not specifically stimulated, coherence did not differ between the two hemispheres for either group. Isler et al. [25] evaluated coherence between two homologous regions of visual cortex during visual stimulation (long latency evoked potentials) in nine children with ASD as compared to neuro-typical controls. The children with ASD demonstrated significantly reduced coherence in the delta and theta spectral bands and essentially no interhemispheric synchronization above the theta band, whereas the neuro-typical children sustained interhemispheric synchrony to higher frequencies. This suggested diminished functional connectivity between the bihemispheric visual regions during visual stimulation in ASD. Leveille et al. [27] assessed resting EEG coherence during REM sleep in nine subjects with ASD compared to neuro-typical controls and reported greater coherence between the left occipital area and both local and distant regions for the children with ASD. They also reported lower