Table 5 shows the corresponding results of AOS meta-analyses. Locus rs578776 was significantly associated with AOS (beta = 0.02, nominal P = 0.004, adjusted P = 0.04). Figure 1A shows the meta-analysis forest plot for the association between rs578776 with a phenotype of AOI while Figure 1B shows these results for AOS. Although the rs578776 locus was not significantly associated with AOI, both betas were 0.02 and suggest that for AOS, the minor allele confers a protective effect because it is associated with a later age of smoking onset. In addition, SNPs rs1948 and rs684513 were associated with AOS (rs1948 beta = 0.023, P = 0.018; rs684513 beta = 0.032, P = 0.017). Figure 2A and B show meta-analysis forest plots for rs1948 with AOI and AOS, respectively. Figure 3A and B show forest plots for rs684513 AOI and AOS, respectively.
