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Chunk #20 — Results — Single SNP Analysis for AOI and AOS Phenotypes

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Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking.
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Tables 4 and 5 show PLINK meta-analysis results for each single locus and the AOI and AOS quantitative phenotypes. Results were nearly identical for both the fixed effects and random effects models. Table 4 presents results of AOI analysis where column one shows the SNP/Locus and columns two and three are the number of contributing datasets and the number of subjects with genotypic and phenotypic information at that SNP/Locus. Columns four and five show the summary beta and P-value, respectively. Column six is the P-value for the Cochrane’s Q statistic. There were no significant associations for AOI at any of the five loci.