Chunk #22 — Materials and methods — Statistical analyses — Polygenic score analyses

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The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data.

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multiplying the dosage score of risk allele count per SNP from 0 to 2 by the beta, summed over all SNPs in the considered set of SNPs and divided by the total number of SNPs.23 In short: ∑dosageScore*beta/N(SNPs). Dosage scores were used to account for the uncertainty in the imputed genotypes. We calculated individual scores for each set of SNPs using the PLINK software.54