Chunk #23 — Materials and methods — Statistical analyses — Polygenic score analyses

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The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data.

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The association of the polygenic scores with MDD was evaluated by logistic regression. Ancestry principal components were included as covariates. The explained variance was based on Nagelkerke's R2. To analyze polygenic scores in the combined samples (GAIN-MDD+MDD2000+ and WTCCC+STEP-BD), polygenic scores were corrected for ancestry principal components. Next, a logistic regression with sample as covariate was performed with standardized residuals of polygenic scores as independent variables.