We estimated the genetic correlation (rg) between traits using LDSC [55]. For PAU, we estimated the rg with 218 published traits in LD Hub [56], 487 unpublished traits from the UK Biobank (integrated in LD Hub), and recently published psychiatric and behavioral traits [9, 32, 34–39, 42, 57, 58], bringing the total number of tested traits to 715 (Supplementary Table 8). For traits reported in multiple studies or in UKB, we selected the published version of the phenotype or used the largest sample size. Bonferroni correction was applied and correlation was considered significant at a p-value threshold of 6.99 × 10-5.
