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Chunk #13 — METHODS — Genomic Information Networks

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SPOT: a web-based tool for using biological databases to prioritize SNPs after a genome-wide association study.
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The final results of the GIN prioritization process may be viewed in an interactive table within the web browser (see the SPOT User’s Guide, https://spot.cgsmd.isi.edu/doc/user_guide.pdf, for screenshots and additional details). The table shows the original P-values and their ranks in the column ‘Rank: p-value’, and the SPOT rankings from the GIN prioritization method in ‘Rank: SPOT’ which are determined by the ‘GIN weighted p-value’ column. The ‘Rank: SPOT’ column is the most important item in the table as it reflects the priority of the SNP from the GIN prioritization method. A graphical column selection tool shown can be used to configure the output tables. The user may select which columns are displayed and their order. This allows the user to view additional information such as detailed gene/mapping properties, HapMap allele frequencies and commercial SNP microarray LD tagging properties. Columns labeled with an asterisk refer to the LD proxy when one is being used, and information about the original or ‘source’ SNP may be viewed using the column selection tool.