Chunk #8 — Methods and Materials — Statistics

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Cortical glutamic acid decarboxylase 67 deficiency results in lower cannabinoid 1 receptor messenger RNA expression: implications for schizophrenia.

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T tests (GAD67+/− and WT mice) or analysis of variance (CB1R+/−, CB1R−/−, and WT mice) were performed to test the effect of genetic condition on OD measures using mean values across all of the sections from each animal, and two-tailed paired t-tests were used to assess group differences in grain density measures. One-tailed Pearson correlation analysis was performed to test the a priori hypothesis that GAD67 mRNA levels positively predict CB1R mRNA levels (6).