Here, we report results from large-scale GWAS of self-reported general risk tolerance (our primary phenotype) and six supplementary phenotypes: “adventurousness” (defined as the self-reported tendency to be adventurous vs. cautious); four risky behaviors: “automobile speeding propensity” (the tendency to drive faster than the speed limit), “drinks per week” (the average number of alcoholic drinks consumed per week), “ever smoker” (whether one has ever been a smoker), and “number of sexual partners” (the lifetime number of sexual partners); and the first principal component (PC) of these four risky behaviors, which we interpret as capturing the general tendency to take risks across domains. All seven phenotypes are coded such that higher phenotype values are associated with higher risk tolerance or risk taking. Table 1 lists, for each GWAS, the datasets we analyzed and the GWAS sample sizes.