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Chunk #2 — INTRODUCTION:

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Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.
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Although risk tolerance has been one of the most studied phenotypes in social science genetics, most claims of positive findings have been based on small-sample candidate gene studies (Supplementary Table 1), whose limitations are now appreciated6. To date, only two loci associated with risk tolerance have been identified in genome-wide association studies (GWAS)7,8.