The age-specific PGS and common factor PGS were not significantly associated with alcohol use in adolescence and early adulthood. The PGS did not improve model fit when tested by LRT (Table 2), accounted for extremely small amounts of phenotypic variance (Table S10), and were not significantly associated with the target phenotype (Table 3). The effect of the age-specific PGS were not significantly larger than the effect of the common factor PGS (adolescence z=−0.35, p=.725; =−1.32, p=.187 early adulthood).
