The age-specific PGS was associated with adult alcohol use frequency when modeled separately from the common factor PGS (B=4.00, SE=1.89, 95% CI [0.31, 7.70]. The association between the common factor PGS and adult alcohol use frequency was not significant when modeled separately from the age-specific PGS (B=3.31, SE=1.59, 95% CI [−0.75, 7.38]. Regression coefficient estimates from analyses with each PGS modeled separately from each other in each developmental period are available in Table S11 and Table S12. Note that the variance accounted for by the age-specific PGS in adulthood (0.1%) is substantially smaller than the variance accounted for by PGS from larger, developmentally-agnostic GWAS (2.4%; Liu et al. 2019). Change pseudo-R2 values for the residual and common factor PGS are reported in Table S10.
