Chunk #21 — Materials and methods — Expression and methylation data integration

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Multi-omics signatures of alcohol use disorder in the dorsal and ventral striatum.

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At the module level, gene-set overlap tests were performed using the R package GeneOverlap (v.1.22.0) [34]. Here, Fisher’s exact test is used to identify significant overlap. For each brain region, the overlap of the AUD-associated co-expression and co-methylation modules was tested.