Chunk #20 — Materials and methods — Expression and methylation data integration

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Multi-omics signatures of alcohol use disorder in the dorsal and ventral striatum.

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To identify genes both DE and differentially methylated, we analyzed the overlap of DE genes (FDR < 0.25) with the results of an EWAS (p < 0.001) in the same sample [15]. We prioritized CpG-sites based on their functional relevance in gene expression regulation. Thus, promoter-associated CpG-sites were used in the analysis.