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Chunk #15 — Statistical Analyses — Mediation analyses

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Impulsiveness mediates the association between GABRA2 SNPs and lifetime alcohol problems.
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yes

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To test the indirect effect, bootstrapping procedures in AMOS were used to examine whether impulsiveness mediated the relation between GABRA2 variants and LAPS. Bootstrapping (MacKinnon et al., 2007) is a non-parametric method based on re-sampling with replacement done 2,000 times. We used a 90% confidence interval. We tested the indirect effect of the four SNPs that were associated with both LAPS and impulsiveness.