Eleven SNPs from the GABRA2 gene spanning from Intron 1 to Intron 9 were analyzed with both the NEO-impulsiveness and the Lifetime Alcohol Problem Scores in the 295 adult subjects. We found ten SNPs associated with the NEO-impulsiveness (p < 0.03) (Table 1). Nine of these associated SNPs were in LD with each other (r2 from 0.71 to 0.96) while one SNP, rs1442060, showed LD (r2) values of less than 0.21 (D′ of 0.51) with the other nine SNPs. These polymorphisms explain between 2.6% and 4.8% of the total variance of impulsiveness. One of the strongest associated SNPs, rs279827 (impulsiveness (p = 0.001), is located next to a splice acceptor site (Figure 1). Similar results were obtained for the Caucasian group (N = 286) providing additional evidence that race does not confound our results. Four out of the ten associated SNPs did not pass multiple correction. These SNPs are located between intron 4 and intron 9.
