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Chunk #17 — Results — GABRA2 variants and the Impulsiveness facet of the Neuroticism domain (NEO-PI)

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Impulsiveness mediates the association between GABRA2 SNPs and lifetime alcohol problems.
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To determine the interdependence of the SNPs, we repeated the association test using one of the most significantly, rs279827, as a conditional factor (covariate). None of the SNPs were longer significant indicating that there are not two or more independent SNPs influencing the association of GABRA2 on impulsiveness. Figure 1 depicts the location of the ten associated SNPs highlighting the strength of the association with impulsiveness around SNP rs279827.