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Chunk #18 — Results — GABRA2 variants and the Impulsiveness facet of the Neuroticism domain (NEO-PI)

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Impulsiveness mediates the association between GABRA2 SNPs and lifetime alcohol problems.
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Covariates in the model (age, gender and race) were not significant and were not included in the final analysis. However, as expected, subjects with an AUD diagnosis had significantly higher impulsiveness scores (16.5 ± 0.40, mean ± s.e.m; p = 0.0003) compared to subjects with no AUD diagnosis (14.8 ± 3.9, mean ± s.e.m.). In the full genetic model, lifetime alcohol use diagnosis as a binary covariate (diagnosis vs no diagnosis) was significant (p < 0.002).