At the facet level (Table 2), the anxiety, angry hostility, and depression aspects of neuroticism increased risk of incident AD by more than 30%; there was a trend for vulnerability (p = 0.05). Among the facets of conscientiousness, self-discipline had the strongest association, followed by competence, order, and dutifulness: risk of incident AD was reduced by over 30% for each SD higher score on any of these facets. Finally, one facet of Openness, Openness to Ideas, was associated significantly with an approximately 25% reduced risk of AD for each SD higher score.
